作者：吴琪patientsimpairedprospective
摘要：Objective To evaluate the feasibility and potential value of comprehensive geriatric assessment(CGA)in elderly(≥60 years)patients with newly diagnosed acute myeloid leukemia(AML)in China.Methods The CGA results of 83 newly diagnosed AML(non-APL)patients from 16 hospitals in Beijing and Tianjin between March 2016 and December 2017 were prospectively collected and analyzed.The clinical data,treatment and follow-up information were also collected.Results Of 83 newly diagnosed elderly AML patients,81 patients(97.6%)completed all designated CGA assessment.The median number of impaired scales of the CGA assessment in the studied population was 2(0-6).Sixteen patients(19.3%)showed no impairments according to the geriatric assessment scales implemented by this study.The distributions of impaired scales were as follows:impairment in ADL,55.4%;IADL impairment,42.2%;MNA-SF impairment,48.2%;cognitive impairment,15.7%;GDS impairment,31.7%;HCT-CI impairment,19.5%,respectively.In patients with“good”ECOG(n=46),the proportion of impairment for each CGA scale ranged from 6.5%to 37.0%and 32 patients(68.9%)had at least one impaired CGA scale.Survival analysis showed that the number of impaired scales of the CGA was significantly correlated with median overall survival(P=0.050).Conclusion CGA was a tool with feasibility for the comprehensive evaluation in elderly AML patients in China.Combined with age and ECOG,CGA may be more comprehensive in assessing patients'physical condition.
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