作者：李玲nafldglp
摘要：Objective Glucagon-like peptide-1 ( GLP-1 ) hasbeen reported to be effective in the treatment of nonalcoholicfatty liver disease (NAFLD). However,the molecularmechanism of GLP-1 on NAFLD is remained unclear.The present study was to detect whether the effectof GLP-1 on triglyceride (TG) content in hepatocytes isdependent on Foxos. Methods HepG2 cells were treatedwith palmitic /oleic acid for 24 h. The knockdown ofFoxo1,Foxo3 was conducted through small interferingRNA (siRNA). Real time PCT (RT-PCR) was used todetect the changes of the SREBP1c and Acox2 genes inHepG2 cells after Foxo1 /3 knockdown. Results As expected,palmitic /oleic acid increased TG concentrationin HepG2 cells [(12. 65 ± 1. 32) μg /mg vs.
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