作者：黄走芳proprognosticsignificanceautologousstemcelltransplantation
摘要：Objective To investigate the prognostic significanceof detection of minimal residual disease after first inductiontreatment (MRD1) in adult acute lymphoblastic leukemia(ALL) patients treated with autologous stem celltransplantation (auto-HSCT). Methods The clinical dataof 87 ALL patients who underwent auto-HSCT duringFebruary 2006 to April 2017 with MRD1 detection databy flow cytometry were analyzed retrospectively. The relationshipbetween MRD1 and relapse and survival ofALL patients after auto-HSCT was studied. Results Of87 patients,26 (29. 9%) were MRD1 positive. The proportionof high-risk immunophenotype ( pro-B,pro-T,pre-T,mature T) was significantly higher in MRD1-positivepatients than that in MRD1 negative patients(34. 6% vs 14. 5%,P = 0. 038). There was no significantdifference between positive and negative MRD1 patientsof age,sex,lineage ( T /B),immunophenotype(standard risk /high risk),high white blood cell count(B-ALL > 30 × 109 /L or T-ALL > 100 × 109 /L),highriskchromosome /gene ratio,the time from first completeremission to transplantation and pre-treatment regimen.
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