作者：张慧expressionlongnoncodingtranscriptionfactorgastriccancer
摘要：Objective To explore the expression and clinicalpathological significance of long non-coding transcriptionfactor 7 ( lncTCF7) in gastric cancer tissues and to investigatethe role of lncTCF7 in the invasion and metastasisof gastric cancer by in vitro experimental study.Methods From January to June 2011,one hundred patientswith gastric cancer who underwent radical gastrectomywere selected from Renji Hospital Affiliated toShanghai Jiaotong University School of Medicine. Theexpression of lncTCF7 at mRNA level was detected byquantitative real-time polymerase chain reaction ( qRTPCR).The patients were divided into high expressiongroup (50 cases) and low expression group (50 cases)according to the lncTCF7 mRNA expression level. Thestable interferenced lncTCF7 cell line ( stable interferencegroup) and blank control lncTCF7 cell line (blankcontrol group) were established. Then the relationshipbetween lncTCF7 expression level and clinical pathologicalcharacteristics and prognosis was analyzed.
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