作者：陈如月clinicalsignificancespd1dl1dl
摘要：Objective To detect the level of soluble programmeddeath 1 (sPD-1) and soluble programmed death ligand 1(sPD-L1) in serum and urine of children with primarynephrotic syndrome (PNS),and explore its clinical significance.Methods From July 2017 to November 2017,children with PNS admitted to the Children's Hospital Affiliatedto Soochow University were divided into onsetgroup (36 cases) and remission group (33 cases). Thirtyhealthy children who underwent medical examinationfor enrollment,undersize or overweight in the outpatientdepartment of pediatric health care and inpatient departmentof Endocrinology were selected as healthy controlgroup. Serum and urine samples were collected, inwhich the levels of sPD-1 and sPD-L1 were detected byenzyme-linked immunosorbent assay (ELISA). The correlationbetween serum and urine sPD-1,sPD-L1 levelsand lymphocyte subsets,urinary protein were analyzedby Pearson and Spearman correlation analysis.
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