作者：Xinghua; Shimechanicstargetdrugdelivery
摘要：The rapid development of nanotechnology enables the successful application of target drug delivery,which provides new hope for the clinical examination and treatment.In the whole process of drug delivery,we foundcouple of mechanics problems existed,including the transportation of nanocarriers,the molecular level target and the cellular uptake of nanoparticles.In recent years,we focused on the investigation of diffusion of drug delivery systems in mucus of gastrointestinal(GI)tract and tumor intestinal.We studied the stiffness effect and geometric effect of nanoparticles in cell internalization,and found that the shape,stiffness and adhesion of nanoparticle-based drug carriers affect their transportation in biological tissues.We revealed the internal mechanism with a theoretical model for the diffusion of nanoparticles in an adhesive/nonadhesive polymer network.These findings shed new light on the design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.
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