作者：Feng; Xuengineeringcellspatiotemporalmechanicalmicroenvironment
摘要：Cells in vivo are in a three-dimensional(3D)complicated microenvironment composed of various biological,physical and chemical cues.Although it is well accepted that biological and chemical cues can significantly influence cell functions,more and more evidence has also shown that physical cues are also vital.Using today’s micro and nanoscale technologies,creating synthetic but native-like conditions are the prerequisites for understanding cell behaviors.Most research has been carried out on artificial two-dimensional(2D)substrates.However,recent studies showed that cells respond and behave differently in these 2D settings compared to in 3D intricate microenvironment.Therefore,innovative 3D in vitro cellular models with precisely patterned multiple types of cells are needed for re-creating distinct niches and in vitro cell modeling under well-defined and reproducible conditions.In this talk,I will present the 3D nano and microscale tissue engineering methods we are developing for engineering cell spatiotemporal mechanical microenvironment.
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