作者：Fukui; S; Tamura; J; Itami; T; Ishizuk...dogsrobenacoxibsevofluranesparingeffects
摘要：Robenacoxib is a newer non-steroidal anti-inflammatory drug (NSAID) and effective for the management of perioperative pain and inflammation. A preoperative administration of robenacoxib is approved in many countries. The preoperative administration of NSAIDs (carprofen or meloxicam) reduces the minimum alveolar concentration (MAC) of sevoflurane during noxious stimulation in dogs (Yamashita et al. 2008). The purpose of this study was to evaluate the effect of robenacoxib on the MAC for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.Six adult healthy beagle dogs were anesthetized to determine the MAC-BAR of sevoflurane on 2-ocassions at least 1-week intervals. In each occasion,the dogs received a subcutaneous injection (SC) of saline (0. 1 ml/kg) or robenacoxib (2 mg/kg) before the MAC-BAR determination. MAC-BAR determination started at 60 minutes after the administration of saline or robenacoxib. MAC-BAR was determined in duplicate for each dog using electrical stimulus applied to the gingival (50 V,50 Hz,10 ms). During the MAC determination,all dogs were mechanically ventilated to maintain the end-tidal CO2within 35 to 40 mmHg and kept warm to maintain esophageal temperature within 37. 5 to 38. 5 ℃. Data were compared between groups using a paired t-test. The level of significance was set at P < 0. 05.The baseline MAC-BAR for sevoflurane was 3. 44 ± 0. 53%. Subcutaneous robenacoxib significantly decreased the sevoflurane MAC-BAR by 17% (2. 84 ± 0. 77%,P = 0. 039).Robenacoxib decreased the sevoflurane MAC-BAR when it was administered at the approved preoperative dose (2mg/kg: SC) to dogs. It is expected that the use of robenscoxib as premedication may provide a clinically relevant anesthetic sparing effect similar to carprofen and meloxicam in dogs (Yamashita et al. 2008).
注：因版权方要求，不能公开全文，如需全文，请咨询杂志社
