研究图文部分
摘要：Chemistry(Huaxue Tongbao),2019,82(10):899~810 Using pregnenlone as a raw material,the titled compounds were designed and synthesized by esterification on 3-hydroxyl and structural modification on 20-carbonyl.Their antiproliferative activities were evaluated by MTT method in vitro.The results showed that compounds 2d and 3d display distinct antiproliferative activity against A549 with IC50 of 7.9μmol/L and 10.3μmol/L,which were not toxic to HEK-293T cells.
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